Insomnia or inadequate sleep has been linked to abnormalities in bones and bone marrow in tests involving animal models.
Researchers lead by Dr Carol Everson at the Medical College of Wisconsin revealed that sleep-deprived rats had unusual bone metabolism serum markers, which resulted in the scientists completing direct measurements of the parameters of their bones.
The international healthcare specialists repeatedly restricted the slumber of rats for 72 days, enabling maladaptions to become present within the animals.
The findings of the study revealed a significant difference between reabsorbtion and bone apposition, which was marked by an impacted bone formation.
Furthermore, the red marrow within the skeleton had greatly diminished levels of fat, while there was double the number of platelet-generating cells, which indicates that marrow plasticity has been altered.
As a result, the investigation, which has had its results published in the journal Experimental Biology and Medicine, found changes to marrow hypercellularity and intramembranous ossification appeared to be caused by chronic sleep loss.
Dr Everson argued that if humans with inadequate slumber sustain the same effects as rats, the medical implications would be "far-reaching".
Expatriate health insurance companies would be interested in the effects sleep has on bone health, which the scientist said could consist of "poor repair of microdamage from activities of daily living, introduction of osteoporotic processes and changes to progenitor cells that may affect disease predisposition and disease resistance".
For example, she pointed out that the researchers' discovery about how a lack of sleep is linked to rising megakaryocyte numbers indicates "there is an increased demand for cell delivery to the circulation consistent with an inflammatory response", which could lead to the development of thrombocytosis.
The co-authors of the paper were Dr Jeffrey Toth and Anne Folley and editor-in-chief of Experimental Biology and Medicine Dr Goodman claimed their findings "will have great impact on our understanding of the impact of sleep deprivation" in humans.
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